Anti-diabetic properties of flavonoid compounds isolated from Hyphaene thebaica epicarp on alloxan induced diabetic rats

被引:53
|
作者
Salib, Josline Y. [1 ]
Michael, Helana N. [1 ]
Eskande, Emad Fawzy [2 ]
机构
[1] Dept Chem Tanning Mat, Cairo, Egypt
[2] Natl Res Ctr, Dept Hormones, Cairo, Egypt
来源
PHARMACOGNOSY RESEARCH | 2013年 / 5卷 / 01期
关键词
Anti-diabetic activity; epicarp; hyphaene thebaica; novel flavonoids;
D O I
10.4103/0974-8490.105644
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Diabetes mellitus, becoming the third killer of mankind after cancer and cardiovascular diseases, is one of the most challenging diseases facing health care professionals today. That is why; there has been a growing interest in the therapeutic use of natural products for diabetes, especially those derived from plants. Aim: To evaluate the anti-diabetic activity together with the accompanying biological effects of the fractions and the new natural compounds of Hyphaene thebaica (HT) epicarp. Materials and Methods: 500 g of coarsely powdered of (HT) fruits epicarp were extracted by acetone. The acetone crude extract was fractionated with methanol and ethyl acetate leaving a residual water-soluble fraction WF . The anti-diabetic effects of the WF and one of its compounds of the acetone extract of the (HT) epicarp were investigated in this study using 40 adult male rats. Results: Phytochemical investigation of active WF revealed the presence of ten different flavonoids, among which two new natural compounds luteolin 7-O-[6 ''-O-alpha-L-rhamnopyranosyl]-beta-D-galactopyranoside 3 and chrysoeriol 7-O-beta-D-galactopyranosyl (1 -> 2)-alpha-L-arabinofuranoside 5 were isolated. Supplementation of the WF improved glucose and insulin tolerance and significantly lowered blood glycosylated hemoglobin levels. On the other hand, compound 5 significantly reduced AST and ALT levels of liver, respectively. Likewise, the kidney functions were improved for both WF and compound 5 , whereby both urea and creatinine levels in serum were highly significant. Conclusion: The results justify the use of WF and compound 5 of the (HT) epicarp as anti-diabetic agent, taking into consideration that the contents of WF were mainly flavonoids.
引用
收藏
页码:22 / 29
页数:8
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