Phytochemical screening and anti-inflammatory activity of Cnidoscolus quercifolius (Euphorbiaceae) in mice

被引：20

作者：

de Araujo Gomes, Leandra Macedo ^{[1
]}

Dantas de Andrade, Thayne Mayra ^{[1
]}

Silva, Juliane Cabral ^{[1
]}

de Lima, Julianeli Tolentino ^{[1
]}

Quintans-Junior, Lucindo Jose ^{[2
]}

Guedes da Silva Almeida, Jackson Roberto ^{[1
]}

机构：

[1] Fed Univ San Francisco Valley, Ctr Studies & Res Med Plants, Collegiate Pharmaceut Sci, Pernambuco, Brazil

[2] Univ Fed Sergipe, Dept Physiol, BR-49100000 Sao Cristovao, Sergipe, Brazil

来源：

PHARMACOGNOSY RESEARCH | 2014年 / 6卷 / 04期

关键词：

Cnidoscolus quercifolius; Euphorbiaceae; inflammation; medicinal plants;

D O I：

10.4103/0974-8490.138290

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Cnidoscolus quercifolius is a species popularly known as "favela" and "faveleira", and belonging to the Caatinga biome (semi-arid vegetation, Brazil), where is used in folk medicine as an anti-inflammatory. Objective: The aim was to evaluate the anti-inflammatory effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of inflammation. Materials and Methods: The preliminary phytochemical analysis of the ethanolic extract was performed. The activity was evaluated by paw edema induced by carrageenan and leukocytes migration to the peritoneal cavity induced by carrageenan methods. Results: A preliminary analysis of Cqb-EtOH revealed that it contained coumarins, flavonoids, monoterpenes/diterpenes and naphthoquinones, while the Cql-EtOH showed positive reaction to coumarins, anthracene derivatives, flavonoids, lignans and triterpenes/steroids. Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan. In the peritonitis test, acute pretreatment with Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited the leukocyte migration. Conclusions: It can be concluded that extracts from the barks and leaves of C. quercifolius have anti-inflammatory activity, which supports the popular use of this plant to treat inflammation. Thus, extracts has significant anti-inflammatory properties, which are related probably to inhibition of release of mediators of the inflammatory process.

引用

页码：345 / 349

页数：5

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