The Role of Uridine Adenosine Tetraphosphate in the Vascular System

被引：24

作者：

Matsumoto, Takayuki ^{[1
,2
]}

Tostes, Rita C. ^{[3
]}

Clinton Webb, R. ^{[1
]}

机构：

[1] Georgia Hlth Sci Univ, Dept Physiol, 1120 Fifteenth St,CA-3135, Augusta, GA 30912 USA

[2] Hoshi Univ, Inst Med Chem, Dept Physiol & Morphol, Shinagawa Ku, Tokyo 1428501, Japan

[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo, SP, Brazil

来源：

ADVANCES IN PHARMACOLOGICAL SCIENCES | 2011年 / 2011卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1155/2011/435132

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4Amodulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

引用

页数：7

共 66 条

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