ISOTYPIC DISTRIBUTION OF ANTI-PYRUVATE DEHYDROGENASE ANTIBODIES IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS AND THEIR FAMILY MEMBERS

被引：5
|
作者：
MARAN, R
DUEYMES, M
ADLER, Y
SHOENFELD, Y
YOUINOU, P
机构：
[1] BREST UNIV,MED SCH HOSP,IMMUNOL LAB,F-29609 BREST,FRANCE
[2] CHAIM SHEBA MED CTR,DEPT MED B,AUTOIMMUNE DIS RES UNIT,IL-52621 TEL HASHOMER,ISRAEL
来源：
JOURNAL OF CLINICAL IMMUNOLOGY | 1994年 / 14卷 / 05期
关键词：
PRIMARY BILIARY CIRRHOSIS; ANTI-PYRUVATE DESHYDROGENASE ANTIBODY; IGG SUBCLASSES;
D O I：
10.1007/BF01540986
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IgG subclasses of anti-pyruvate dehydrogenase (PDH) antibodies were determined in 72 patients with primary biliary cirrhosis. All isotypes were detected, but IgG3, IgG1, and IgG2 predominated independently or in association. An average of 33.3 +/- 19.1% of the anti-PDH IgG was IgG1 (mean optical density, 0.863 +/- 0.783, vs 0.053 +/- 0.038 in the normal controls), 25.0 +/- 17.8 IgG2 (0.652 +/- 0.656 vs 0.062 +/- 0.030), 39.5 +/- 23.4% IgG3 (1.140 +/- 0.917 vs 0.010 +/- 0.023), and 2.4 +/- 7.4% IgG4 (0.060 +/- 0.182 vs 0.012 +/- 0.007). Anti-PDH IgG were restricted to IgG1 in the family members of patients (0.180 +/- 0.403).
引用
收藏
页码：323 / 326
页数：4
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