THE ROLE OF SEROTONIN AND DOPAMINE IN BRAIN IN THE ANTIDEPRESSANT-LIKE EFFECT OF CLONIDINE IN THE FORCED SWIMMING TEST

被引：6
|
作者：
CERVO, L [1 ]
ROSSI, C [1 ]
SAMANIN, R [1 ]
机构：
[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY
来源：
NEUROPHARMACOLOGY | 1992年 / 31卷 / 04期
关键词：
CLONIDINE; ANTIDEPRESSANT ACTIVITY; SEROTONIN; DOPAMINE; MESOLIMBIC SYSTEM; RAT;
D O I：
10.1016/0028-3908(92)90064-V
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of clonidine (0.1 mg/kg, i.p.), as a three-injection course, on behaviour in the forced swimming test was studied in rats injected intracerebroventricularly (i.c.v.) with 150-mu-g 5,7-dihydroxytryptamine (5,7-DHT) to destroy serotonin (5-HT) neurones or treated with 100 mg/kg (i.p.) (+/-)-sulpiride or 0.5-mu-g/0.5-mu-l (-)-sulpiride in the nucleus accumbens. Clonidine significantly increased struggling and reduced floating and the effects were antagonized by both treatments with sulpiride but not by 5,7-DHT which markedly depleted 5-HT in brain. The results suggest that the mesolimbic dopaminergic system but not 5-HT neurones, plays a permissive role in the antidepressant-like effect of clonidine in the forced swimming test.
引用
收藏
页码：331 / 335
页数：5
相关论文
共 50 条
  • [1] Antidepressant-like action of nicotine in forced swimming test and brain serotonin in mice
    Suemaru, Katsuya
    Yasuda, Kayo
    Cui, Ranji
    Li, Bingjin
    Umeda, Kenta
    Amano, Manabu
    Mitsuhashi, Hiromi
    Takeuchi, Nobuhito
    Inoue, Tornoyoshi
    Gomita, Yutaka
    Araki, Hiroaki
    PHYSIOLOGY & BEHAVIOR, 2006, 88 (4-5) : 545 - 549
  • [2] Is dopamine a limiting factor of the antidepressant-like effect in the mouse forced swimming test?
    Renard, CE
    Dailly, E
    Nic Dhonnchadha, BA
    Hascoet, M
    Bourin, M
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2004, 28 (08): : 1255 - 1259
  • [3] Dopamine is involved in the antidepressant-like effect of allopregnanolone in the forced swimming test in female rats
    D'Aquila, Paolo S.
    Canu, Silvia
    Sardella, Marco
    Spanu, Caterina
    Serra, Gino
    Franconi, Flavia
    BEHAVIOURAL PHARMACOLOGY, 2010, 21 (01): : 21 - 28
  • [4] Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?
    Caroline E. Renard
    Alexandra J. Fiocco
    Florence Clenet
    Martine Hascoet
    Michel Bourin
    Psychopharmacology, 2001, 159 : 42 - 50
  • [5] Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?
    Bourin, M.
    Renard, C.
    Fiocco, A. J.
    Clenet, F.
    Hascoet, M.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2001, 15 : 81 - 81
  • [6] Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?
    Renard, CE
    Fiocco, AJ
    Clenet, F
    Hascoet, M
    Bourin, M
    PSYCHOPHARMACOLOGY, 2001, 159 (01) : 42 - 50
  • [7] The antidepressant-like effect of selegiline on forced swimming test in mice
    Shimazu, S
    Kusumoto, H
    Minami, A
    Yoneda, F
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S282 - S282
  • [8] The antidepressant-like effect of selegiline on forced swimming test in mice
    Kusumoto, H
    Minami, A
    Shimazu, S
    Yoneda, F
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 164P - 164P
  • [9] Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test
    Ulak, Guener
    Mutlu, Oguz
    Tanyeri, Pelin
    Komsuoglu, F. Ipek
    Akar, Fueruzan Yildiz
    Erden, B. Faruk
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2010, 95 (03) : 308 - 314
  • [10] The role of the serotonergic system in the antidepressant-like effect of TRIM in the rat forced swimming test
    Tanyeri, P.
    Mutlu, O.
    Akar, F. Y.
    Komsuoglu, I.
    Ulak, G.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 : 66 - 66
12345