THE EFFECTS OF TESTICULAR TRAUMA ON FERTILITY IN THE LEWIS RAT AND COMPARISONS TO ISOIMMUNIZED RECIPIENTS OF SYNGENEIC SPERM

被引：30

作者：

SLAVIS, SA ^{[1
]}

SCHOLZ, JN ^{[1
]}

HEWITT, CW ^{[1
]}

BLACK, KS ^{[1
]}

CAMPBELL, RS ^{[1
]}

PATEL, M ^{[1
]}

ZIMMERMAN, J ^{[1
]}

PEAKE, ML ^{[1
]}

MARTIN, DC ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT SURG,DIV UROL,TRANSPLANTAT LAB,MED SCI 1, B150, IRVINE, CA 92717 USA

来源：

JOURNAL OF UROLOGY | 1990年 / 143卷 / 03期

关键词：

D O I：

10.1016/S0022-5347(17)40046-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Adult male Lewis (LEW) rats were used to investigate the effects of unilateral testicular trauma on fertility. Comparisons were made between normal and experimental rats immunized with syngeneic sperm in Complete Freund's Adjuvant (CFA). Matings within the three groups yielded offspring to all normal males, no offspring to the immunized rats, and 27% (3/11) fertility in the trauma group (p < 0.001). The contralateral testis demonstrated decreased volumes, various degrees of aspermatogenesis and smaller seminiferous tubular diameters, in both the trauma and immunized groups compared to the controls. Similar histopathologic findings of chronic granulomatous inflammation within contralateral testes in both the trauma and immunized groups suggested a common immune etiology for infertility via possible disruption of the blood-testis barrier.

引用

页码：638 / 641

页数：4