SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL MANIFESTATIONS AND IMMUNOLOGICAL PARAMETERS IN 194 PATIENTS - SUBGROUP CLASSIFICATION OF SLE

被引：22

作者：

ANTOLIN, J

AMERIGO, MJ

CANTABRANA, A

ROCES, A

JIMENEZ, P

机构：

[1] Internal Medicine Services 'Ntra. Sra. de La Candelaria' Hospital, Tenerife and 'Ntra. Sra. del Pino', Las Palmas

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷 / 06期

关键词：

MANIFESTATIONS; IMMUNOLOGICAL PARAMETERS; SLE SUBGROUPS;

D O I：

10.1007/BF02207936

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We analysed the prevalence of clinical manifestations and immunological parameters in 194 patients with SLE and classified them in subgroups according to age at onset, gender and type of antibodies: we detected significant differences in the various subgroups. In SLE that initiated before the age of 20 years, the most frequent manifestation at onset was malar rash (25% vs 14%), During the course of the disease, this group had a greater prevalence of malar rash (70% vs 45%), mouth ulcers (48% vs 29%), and convulsions or psychosis (35% vs 17%). In SLE that initiated late in life (after 50 years) malar rash was less frequent at onset and during subsequent evolution of the disease (27% vs 45%), The existence of ANA, and elevated values of anti-dsDNA, anti-ENA and antiphospholipid antibodies also differentiated the SLE subgroups with clinical significance.

引用

页码：678 / 685

页数：8

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