INTERFERON THERAPY FOR BEHCETS-DISEASE

被引:47
作者
ALPSOY, E
YILMAZ, E
BASARAN, E
机构
关键词
D O I
10.1016/S0190-9622(94)70226-8
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Behcet's disease was first described in 1937 as a trisymptom complex. No standard therapy has been established. Tts cause is presumed to be viral or immunologic. Objective: We sought to determine whether patients with Behcet's disease benefit from interferon, which has antiviral, immunomodulatory, antiproliferative, and antitumoral properties. Methods: Fourteen patients were initially given 3 MU interferon alfa-2a subcutaneously three times per week. The doses were gradually increased to 12 MU. Each patient received a total dose of 216 MU during the 2-month study. Therapy with 9 MU interferon alfa-2a once a month was continued in half the patients. Ah patients were observed before and after treatment for 6-month periods, and all symptoms were recorded. Results: All patients were symptom free by the end of the 2-month treatment period. The frequencies of oral and genital ulcers as well as pustular vasculitis decreased significantly in the posttreatment period as compared with the pretreatment period. Conclusion: The data suggest that interferon treatment appears to be effective for patients with Behcet's disease.
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页码:617 / 619
页数:3
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