MACQUARIMICINS, MICROBIAL METABOLITES FROM MICROMONOSPORA .2. ISOLATION AND STRUCTURAL ELUCIDATION

被引：25

作者：

HOCHLOWSKI, JE

MULLALLY, MM

HENRY, R

WHITTERN, DM

MCALPINE, JB

机构：

[1] New Lead Discovery, Abbott Laboratories, Abbott Park

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 06期

关键词：

D O I：

10.7164/antibiotics.48.467

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel series of carbocyclic compounds has been isolated from two related Micromonospora cultures. The C-19 and C-22 macquarimicins represent different end products on a similar biosynthetic scheme. 1-D and 2-D homonuclear and heteronuclear NMR experiments allowed assignment of the basic structures of the macquarimicins. An X-ray structure of macquarimicin B suggested the stereochemistry for the series which was not discernible from spectroscopic data alone.

引用

页码：467 / 470

页数：4

共 10 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].