INHIBITION OF ENDOTHELIN-1 INDUCED DNA-SYNTHESIS BY PROSTACYCLIN AND ITS STABLE ANALOGS IN VASCULAR SMOOTH-MUSCLE CELLS

被引:8
|
作者
NAKAKI, T
OHTA, M
KATO, R
机构
[1] Department of Pharmacology, Keio University School of Medicine, Tokyo
关键词
PROSTACYCLIN; DNA SYNTHESIS; VASCULAR SMOOTH MUSCLE CELLS; ENDOTHELIN;
D O I
10.1097/00005344-199100177-00050
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of prostacyclin and its stable analogues on endothelin-induced DNA synthesis were investigated in cultured vascular smooth muscle cells. Aortic smooth muscle cells were obtained from male Wistar rats. In order to eliminate endothelial cells, the cells were cloned. DNA synthesis in intact cells was estimated by [H-3]thymidine incorporation. Prostacyclin and its stable analogues (TEI-7165, TEI-9090, TEI-1324, TEI-3356, and TEI-9063) inhibited the endothelin-induced DNA synthesis with an IC50 of 1-30 nM. These results indicate that prostacyclin and its stable analogues are possibly effective in preventing the proliferation of vascular smooth muscle cells under some pathological situations, including atherosclerosis.
引用
收藏
页码:S177 / S178
页数:2
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