Lactose intolerance: diagnosis, genetic, and clinical factors

被引：134

作者：

Mattar, Rejane ^{[1
]}

de Campos Mazo, Daniel Ferraz ^{[1
]}

Carrilho, Flair Jose ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo, Brazil

来源：

CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY | 2012年 / 5卷

关键词：

hypolactasia; lactase persistence; lactase non-persistence; lactose; LCT gene; MCM6; gene;

D O I：

10.2147/CEG.S32368

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Most people are born with the ability to digest lactose, the major carbohydrate in milk and the main source of nutrition until weaning. Approximately 75% of the world's population loses this ability at some point, while others can digest lactose into adulthood. This review discusses the lactase-persistence alleles that have arisen in different populations around the world, diagnosis of lactose intolerance, and its symptomatology and management.

引用

页码：113 / 121

页数：9

共 80 条

[1] Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT-13910C>T mutation [J].

Almon, Ricardo ;

Engfeldt, Peter ;

Tysk, Curt ;

Sjostrom, Michael ;

Nilsson, Torbjorn K. .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2007, 42 (02) :165-170

[2] Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands [J].

Almon, Ricardo ;

Alvarez-Leon, Eva E. ;

Engfeldt, Peter ;

Serra-Majem, Lluis ;

Magnuson, Anders ;

Nilsson, Torbjorn K. .

EUROPEAN JOURNAL OF NUTRITION, 2010, 49 (03) :141-146

[3] Tracing the Distribution and Evolution of Lactase Persistence in Southern Europe Through the Study of the T-13910 Variant [J].

Anagnostou, Paolo ;

Battaggia, Cinzia ;

Coia, Valentina ;

Capelli, Cristian ;

Fabbri, Cristina ;

Pettener, Davide ;

Destro-Bisol, Giovanni ;

Luiselli, Donata .

AMERICAN JOURNAL OF HUMAN BIOLOGY, 2009, 21 (02) :217-219

[4] Frequency of lactose malabsorption among healthy southern and northern Indian populations by genetic analysis and lactose hydrogen breath and tolerance tests [J].

Babu, Janaki ;

Kumar, Sunil ;

Babu, P. ;

Prasad, Jaishri H. ;

Ghoshal, Uday C. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (01) :140-146

[5] LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women [J].

Bacsi, K. ;

Kosa, J. P. ;

Lazary, A. ;

Balla, B. ;

Horvath, H. ;

Kis, A. ;

Nagy, Z. ;

Takacs, I. ;

Lakatos, P. ;

Speer, G. .

OSTEOPOROSIS INTERNATIONAL, 2009, 20 (04) :639-645

[6] Genotyping of the lactase-phlorizin hydrolase-13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance [J].

Bodlaj, G ;

Stöcher, M ;

Hufnagl, P ;

Hubmann, R ;

Biesenbach, G ;

Stekel, H ;

Berg, J .

CLINICAL CHEMISTRY, 2006, 52 (01) :148-151

[7]

BOLL W, 1991, AM J HUM GENET, V48, P889

[8] Introducing genetic testing for adult-type hypolactasia [J].

Büning, C ;

Genschel, J ;

Jurga, J ;

Fiedler, T ;

Voderholzer, W ;

Fiedler, EM ;

Worm, M ;

Weltrich, R ;

Lochs, H ;

Schmidt, H ;

Ockenga, J .

DIGESTION, 2005, 71 (04) :245-250

[9] Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome [J].

Campbell, A. K. ;

Matthews, S. B. ;

Vassel, N. ;

Cox, C. D. ;

Naseem, R. ;

Chaichi, J. ;

Holland, I. B. ;

Green, J. ;

Wann, K. T. .

TOXICOLOGY, 2010, 278 (03) :268-276

[10] Subjective Perception of Lactose Intolerance Does Not Always Indicate Lactose Malabsorption [J].

Casellas, Francesc ;

Aparici, Anna ;

Casaus, Maite ;

Rodriguez, Purificacion ;

Malagelada, Juan R. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2010, 8 (07) :581-586

← 1 2 3 4 5 6 7 8 →