RANKING TOXICITY OF INDUSTRIAL DUSTS BY BRONCHOALVEOLAR LAVAGE FLUID ANALYSIS

被引：10

作者：

BAJPAI, R ^{[1
]}

WASEEM, M ^{[1
]}

GUPTA, GSD ^{[1
]}

KAW, JL ^{[1
]}

机构：

[1] IND TOXICOL RES CTR, POST BOX 80, MG MARG, LUCKNOW 226001, UTTAR PRADESH, INDIA

来源：

TOXICOLOGY | 1992年 / 73卷 / 02期

关键词：

BRONCHOALVEOLAR LAVAGE; DUSTS; TOXICITY; LUNG;

D O I：

10.1016/0300-483X(92)90099-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Female wistar rats were inoculated intratracheally with 10 mg/ml suspensions of various dusts, viz: quartz, fly ash, mica and corundum in physiological saline. Biochemical markers of bronchoalveolar lavage fluid (BALF) were analysed 8 days after the instillation of the dusts. Elevated levels of proteins, sialic acid and phospholipid contents and the activity of lactate dehydrogenase correlated well with the degree of the known fibrogenic potential of different dusts in the lungs in the following order, quartz > fly ash > mica > corundum. Beta-glucuronidase activity, was however, only elevated in the quartz inoculated group of rats. It is suggested that biochemical constituents of BALF analysed shortly after the exposure to different dusts can be useful to mirror alterations in the tissue response to mineral dusts.

引用

页码：161 / 167

页数：7

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