ZONA-PELLUCIDA INDUCES CONVERSION OF PROACROSIN TO ACROSIN

被引：30
|
作者：
TOPFERPETERSEN, E [1 ]
CECHOVA, D [1 ]
机构：
[1] CZECHOSLOVAK ACAD SCI, INST MOLEC GENET, CS-11142 PRAGUE 1, CZECHOSLOVAKIA
来源：
INTERNATIONAL JOURNAL OF ANDROLOGY | 1990年 / 13卷 / 03期
关键词：
acrosin; proacrosin; sperm penetraton; zona pellucida; zymogen activation;
D O I：
10.1111/j.1365-2605.1990.tb00976.x
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
The effect of heat‐solubilized zonae pellucidae (ZP) isolated from mature pig ovaries on the conversion of pig proacrosin to acrosin was examined and compared with the effects of different sulphated polysaccharides. At low concentrations, zona glycoproteins potently stimulated acrosin auto‐activation. Up to 2.5 μg ml‐1 ZP, the acceleration of acrosin activation was shown to be dependent on the ZP concentration. At higher concentrations zona glycoproteins exerted an inhibitory effect on acrosin amidase activity. A similar effect was demonstrated for fucoidan, heparin, and chondroitin sulphate. The results intimate that in vivo, the conversion of proacrosin to acrosin is regulated at the sperm‐zona interface. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：190 / 196
页数：7
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