QUANTITATION AND LINEARITY FOR PARTICLE-BEAM LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：42

作者：

APFFEL, A ^{[1
]}

PERRY, ML ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 554卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)88441-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Quantitative performance for a particle-beam liquid chromatography-mass spectrometry system is evaluated with particular attention to non-linear behavior at low concentrations. A mathematical model for the non-linear behavior is proposed and shown to be in agreement with experimental data. The effects of 10 high-performance liquid chromatography mobile phase additives and 24 analytical probes on the linearity are shown. Although certain combinations of probes and additives show improved linear response, no single additive appears to completely alleviate the non-linear behavior as has been suggested by earlier work.

引用

页码：103 / 118

页数：16

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