Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus

被引：40

作者：

Little, Z ^{[1
]}

Grover, LM ^{[1
]}

Teyler, TJ ^{[1
]}

机构：

[1] MARSHALL UNIV,SCH MED,DEPT PHYSIOL,HUNTINGTON,WV 25704

来源：

NEUROSCIENCE LETTERS | 1995年 / 201卷 / 01期

关键词：

hippocampus; glutamate; long-term potentiation; metabotropic glutamate receptor; N-methyl-D-aspartate receptor; calcium channel;

D O I：

10.1016/0304-3940(95)12141-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two independent forms of LTP. One form induced by a 25 Hz/1 s tetanus is solely N-methyl-D-aspartate (NMDA) receptor-dependent. The other form induced by four 200 Hz/0.5 s bursts in the presence of APV is NMDA receptor-independent. In both paradigms the presence of MCPG prevented the induction of LTP by afferent activation.

引用

页码：73 / 76

页数：4

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