DIM LIGHT MELATONIN ONSET AND CIRCADIAN TEMPERATURE DURING A CONSTANT ROUTINE IN HYPERSOMNIC WINTER DEPRESSION

被引:79
作者
DAHL, K
AVERY, DH
LEWY, AJ
SAVAGE, MV
BRENGELMANN, GL
LARSEN, LH
VITIELLO, MV
PRINZ, PN
机构
[1] UNIV WASHINGTON, DEPT PHYSIOL & BIOPHYS, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, DEPT PSYCHOL, SEATTLE, WA 98195 USA
[3] UNIV WASHINGTON, DEPT BEHAV SCI, SEATTLE, WA 98195 USA
[4] UNIV WASHINGTON, DEPT PSYCHIAT, SEATTLE, WA 98195 USA
[5] OREGON HLTH SCI UNIV, DEPT PSYCHIAT, PORTLAND, OR 97201 USA
[6] OREGON HLTH SCI UNIV, DEPT OPHTHALMOL, PORTLAND, OR 97201 USA
[7] OREGON HLTH SCI UNIV, DEPT PHARMACOL, PORTLAND, OR 97201 USA
[8] SIMON FRASER UNIV, SCH KINESIOL, BURNABY V5A 1S6, BC, CANADA
关键词
SEASONAL AFFECTIVE DISORDER; CIRCADIAN RHYTHM; MELATONIN; LIGHT THERAPY;
D O I
10.1111/j.1600-0447.1993.tb03414.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The onset of melatonin secretion under dim light conditions (DLMO) and the circadian temperature rhythm during a constant routine were assessed in 6 female controls and 6 female patients with winter depression (seasonal affective disorder, SAD) before and after bright light treatment. After sleep was standardized for 6 days, the subjects were sleep-deprived and at bedrest for 27 h while core temperature and evening melatonin levels were determined. The DLMO of the SAD patients was phase-delayed compared with controls (2310 vs 2138); with bright light treatment, the DLMO advanced (2310 to 2135). The minimum of the fitted rectal temperature rhythm was phase-delayed in the SAD group compared with the controls (0542 vs 0316); with bright light treatment, the minimum advanced (0542 vs 0336).
引用
收藏
页码:60 / 66
页数:7
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