Calcium alginate-based antimicrobial film dressings for potential healing of infected foot ulcers

被引：44
作者：
Ahmed, Asif [1 ]
Boateng, Joshua [1 ]
机构：
[1] Univ Greenwich, Fac Engn & Sci, Dept Pharmaceut Chem & Environm Sci, Cent Ave Chatham Maritime, Chatham ME4 4TB, Kent, England
来源：
THERAPEUTIC DELIVERY | 2018年 / 9卷 / 03期
关键词：
antibacterial activity; calcium alginate; chronic wounds; ciprofloxacin; diabetic foot ulcers; glycerol; moisture handling; solvent cast film; wound healing;
D O I：
10.4155/tde-2017-0104
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection. Results/methodology: Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Films were transparent, flexible, uniform, with ideal moisture handling, maximum drug release within 90 min, killing bacteria within 24 h and highly biocompatible with human keratinocyte cells. Conclusion: The results confirmed successful design of biocompatible dressings effective against Gram-positive and Gram-negative bacteria. [GRAPHICS]
引用
收藏
页码：185 / 204
页数：20
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