THE SWISS HIV COHORT STUDY - RATIONALE, ORGANIZATION AND SELECTED BASE-LINE CHARACTERISTICS

被引：147

作者：

LEDERGERBER, B ^{[1
]}

VONOVERBECK, J ^{[1
]}

EGGER, M ^{[1
]}

LUTHY, R ^{[1
]}

BUCHER, H ^{[1
]}

ERB, P ^{[1
]}

MATTER, L ^{[1
]}

PICHLER, WJ ^{[1
]}

HIRSCHEL, B ^{[1
]}

PERRIN, L ^{[1
]}

FRANCIOLI, P ^{[1
]}

FREI, P ^{[1
]}

FIERZ, W ^{[1
]}

VERNAZZA, P ^{[1
]}

GROB, PJ ^{[1
]}

GUTZWILLER, F ^{[1
]}

HEUSSER, R ^{[1
]}

KNOPFLI, D ^{[1
]}

BUNDSCHU, B ^{[1
]}

HACHLER, I ^{[1
]}

MEISTER, T ^{[1
]}

机构：

[1] UNIV ZURICH HOSP, DEPT MED, DIV INFECT DIS, CH-8091 ZURICH, SWITZERLAND

来源：

SOZIAL-UND PRAVENTIVMEDIZIN | 1994年 / 39卷 / 06期

关键词：

D O I：

10.1007/BF01299670

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives: This paper describes the rationale and design features of the Swiss HIV Cohort Study (SHCS) and the baseline characteristics of participants enrolled up to March 31st 1993. The objectives include epidemiological, clinical and laboratory research. Design: The SHCS is a prospective cohort study of HIV infected adolescents and adults seen at the outpatient clinics of the Swiss University Hospitals in Basle, Berne, Geneva, Lausanne and Zurich and the Cantonal Hospital St. Gall. The multicentre collaboration was initiated in September 1988 by the Swiss Federal Office of Public Health. Data collected prior to this date by several participating centers using a similar protocol were included, the earliest records dating back to 1982. Follow-up visits are scheduled every 6 months. Enrollment: As of March 31st 1993, 6253 participants (M: 4580, F: 1675) were included with a total of 16015 person-years of follow-up (mean 2.6 years). HIV transmission categories were 44%,intravenous drug users (IDU) 32% men who had sex with men (MSM) 18% heterosexual contacts (HET) and 4% other The proportion of MSM among male participants decreased from 62% in 1385 to 40% in 1987, to remain stable thereafter: The proportion of IDU among males was around 40% throughout, whereas in females, there was a pronounced decline from 90% IDU in 1985 to 50% in 1992. Conversely there was a striking increase in registrations of women presumably infected by HET from 8% in 1985 to 50% in 1932. Among men, the proportion classified as HET increased from 2% to 15%. It is estimated, that a large proportion of all Swiss AIDS patients (70%) and HIV infected individuals (32%-47%) are enrolled in the Swiss HIV Cohort Study Losses to follow-up, however are common. Conclusions: The SHCS serves multiple purposes as a research project, as infrastructure for multidisciplinary research and as a tool to improve patient care. Several international and national trials, post-marketing surveillances and expanded access protocols were or still are based upon its infrastructure. The large number of female participants and of participants AIDS-free at entry make the database especially valuable.

引用

页码：387 / 394

页数：8

共 7 条

[1]

Grob P.J., The HIV epidemic in Switzerland (in German and French), Bull BAG, 40, pp. 712-725, (1993)

[2]

Engel R.R., Samuel M.C., Rieder H.L., Billo N., Somaini B., Completeness of AIDS reporting in Switzerland: a study based on deaths between December 1987 and June 1990, AIDS, 6, pp. 1385-1389, (1992)

[3]

von Overbeck J., Egger M., Smith G.D., Ledergerber B., Survival in HIV infection: do sex and category of transmission matter?, AIDS, 8, pp. 1307-1313, (1994)

[4]

Frei A., Hill S., Das Schweizerische Gesundheitswesen: Zahlenspiegel, Anbieter von Gesundheitsgütern, Preisbildung, Organisationsstrukturen, (1992)

[5]

Hirschel B., Lazzarin A., Chopard P., Et al., A controlled study of inhaled pentamidine for primary prevention of Pneumocystis carinii pneumonia, N Engl J Med, 324, pp. 1079-1083, (1991)

[6]

Heald A., Flepp M., Chave J.P., Et al., Treatment for cerebral toxoplasmosis protects against Pneumocystis carinii pneumonia in patients with AIDS, Ann Interna Med, 115, pp. 760-763, (1991)

[7]

Bottger E.C., Teske A., Krischner P., Et al., Disseminated “Mycobacterium genavense” infection in patients with AIDS, Lancet, 340, pp. 76-80, (1992)

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