CYCLOSPORINE IN RHEUMATOID-ARTHRITIS - AN OVERVIEW

被引：9

作者：

FORRE, O

机构：

[1] Oslo Sanitetsforenings Rheumatism Hospital, Oslo, 0172

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷

关键词：

RHEUMATOID ARTHRITIS; CYCLOSPORINE; LARSEN SCORE;

D O I：

10.1007/BF02215856

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

All the studies so far performed indicate that Cyclosporine (CyA) treatment i RA is effective and one study indicates that it can also slow down radiological progression. But it is also clear that CyA induced nephrotoxicity is so far the main problem, However, nephrotoxicity can be minimised by lowering the CyA dosage and by ensuring that RA patients subjected to CyA therapy have a normal kidney function and no history of hypertension. I believe that CyA alone or in combination with other drugs will find its place in the treatment of RA and other autoimmune diseases in the near future.

引用

页码：33 / 36

页数：4

共 19 条

[1]

Janossy G., Duke O., Poulter L.W., Panayi G., Bofill M., Goldstein G., Rheumatoid arthritis: a disease of T lymphocyte/macrophage immunoregulation, Lancet, 2, pp. 839-844, (1981)

[2]

Waalen K., Forre O., Linker-Israeli M., Thoen J., Evidence of an activated T-cell system with augmented turnover of interleukin 2 in rheumatoid arthritis. Simulation of human T lymphocytes by dendritic cells as a model for rheumatoid T cell activation, Scand J Immunol, 25, pp. 367-373, (1987)

[3]

Kronke M., Leonard W.J., Depper J.M., Et al., Cyclosporine A inhibits T-cell growth factor gene expression at the level of mRNA transcription, Proc Natl Acad Sci USA, 81, pp. 5214-5218, (1983)

[4]

Borel J.F., Wiesinger D., Bubler H.V., Effects of the anti-lymphocytic agent Cyclosporine. A chronic inflammation, Eur J Rheumatol Inflamm, 1, pp. 237-244, (1978)

[5]

Keown P.A., Stiller C.R., Stawecki M., McMichael J., Howson W., Pharmacokinetics and interactions of Cyclosporine, Cyclosporine in autoimmune diseases, pp. 39-42, (1985)

[6]

Tugwell P., Bombardier C., Gent M., Et al., Low-dose Cyclosporine versus placebo in patients with rheumatoid arthritis, Lancet, 335, pp. 1051-1105, (1990)

[7]

Dougados M., Awada H., Amor B., Cyclosporine in rheumatoid arthritis: a double-blind, placebo controlled study in 52 patients, Ann Rheum Dis, 47, pp. 127-133, (1988)

[8]

Van Rijthoven A.W., Dijkmans B.A., Goei, Et al., Comparison of Cyclosporine and D-penicillamine for rheumatoid arthritis: a randomised, double-blind multicentre study, J Rheumatol, 18, pp. 815-820, (1991)

[9]

Kruger K., Schattenkirchner M., Cyclosporine A vs azathioprine in the treatment of RA — results of a controlled multicentre double-blind study (abstract), J Autoimmun, 5, (1992)

[10]

Landewe R.B.M., Goei, van Rijthoven A.W.A.M., Breedveld F.C., Dijkmans B.A., A randomised, double-blind, 24 week controlled study of low-dose cyclosporin versus chloroquine for early rheumatoid arthritis, Arthritis & Rheumatism, 37, pp. 637-643, (1994)

← 1 2 →