THE INFLUENCE OF 2-CHLORODEOXYADENOSINE IN COMBINATION WITH TUMOR-NECROSIS-FACTOR-ALPHA OR ITS MUTEIN ON MURINE LEUKEMIAS L1210 AND P388

被引：2

作者：

GORATYBOR, J

WARZOCHA, K

ROBAK, T

机构：

[1] MED UNIV LODZ,DEPT PHARMACOL,LODZ,POLAND

[2] MED UNIV LODZ,DEPT INTERNAL MED 2,PL-93513 LODZ,POLAND

来源：

MEDIATORS OF INFLAMMATION | 1995年 / 4卷 / 03期

关键词：

2-CHLORODEOXYADENOSINE; EXPERIMENTAL LEUKEMIAS; INTERACTIONS OF CYTOKINES AND ANTINEOPLASTIC DRUGS; MUTEINS OF TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTOR-ALPHA;

D O I：

10.1155/S0962935195000330

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

WE investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNF alpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia L1210 and P388 receiving 2-CdA combined with TNF alpha had shorter survival times than animals treated with these agents separately. In contrast, the administration of 2-CdA in conjunction with mutein VI, prolonged the survival of mice inoculated with these leukaemias as compared with animals receiving these agents separately. The results of the present study emphasize the importance of the biological activity of the TNF alpha molecule N-terminus.

引用

页码：205 / 208

页数：4

共 17 条

[1] MODULATION OF LEUKOCYTE GENETIC EXPRESSION BY NOVEL PURINE NUCLEOSIDE ANALOGS - A NEW APPROACH TO ANTITUMOR AND ANTIVIRAL AGENTS [J].