ANGIOTENSIN-II SIGNAL-TRANSDUCTION AND THE MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAY

被引：65
作者：
DUFF, JL
MARRERO, MB
PAXTON, WG
SCHIEFFER, B
BERNSTEIN, KE
BERK, BC
机构：
[1] EMORY UNIV, DEPT BIOCHEM, ATLANTA, GA 30322 USA
[2] EMORY UNIV, DEPT PATHOL, ATLANTA, GA 30322 USA
[3] UNIV WASHINGTON, DEPT MED, DIV CARDIOL, SEATTLE, WA USA
来源：
CARDIOVASCULAR RESEARCH | 1995年 / 30卷 / 04期
关键词：
ANGIOTENSIN II; MAP KINASE; VASCULAR SMOOTH MUSCLE; HYPERTROPHY; SIGNAL TRANSDUCTION; PROTEIN KINASE C;
D O I：
10.1016/0008-6363(95)00088-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.
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收藏
页码：511 / 517
页数：7
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