A CRF ANTAGONIST ATTENUATES STRESS-INDUCED INCREASES IN NA TURNOVER IN EXTENDED BRAIN-REGIONS IN RATS

被引：37
作者：
EMOTO, H
KOGA, C
ISHII, H
YOKOO, H
YOSHIDA, M
TANAKA, M
机构：
[1] Department of Pharmacology, Kurume University School of Medicine, Kurume
来源：
BRAIN RESEARCH | 1993年 / 627卷 / 01期
关键词：
CRF; NORADRENALINE; MHPG-SO(4); STRESS; BRAIN REGION; CORTICOSTERONE; CRF ANTAGONIST; ALPHA-HELICAL CRF(9-41);
D O I：
10.1016/0006-8993(93)90762-C
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the effects of intracerebroventricular (i.c.v.) administration of a corticotropin-releasing factor (CRF) antagonist, alpha-helical CRF9-41 (ahCRF), on increases in noradrenaline (NA) turnover caused by immobilization stress in rat brain regions. Pretreatment with ahCRF (50 or 100 mug) significantly attenuated increases in levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4), the major metabolite of NA in rat brain, in the locus coeruleus (LC) region. and attenuated the MHPG-SO4/NA ratio after immobilization stress for 50 min in the cerebral cortex, hippocampus, amygdala, midbrain and hypothalamus. However, stress-induced increases in plasma corticosterone levels were not decreased significantly by pretreatment with ahCRF. These results suggest that CRF, released during stress, causes increases in NA release in extended brain regions of stressed rats.
引用
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页码：171 / 176
页数：6
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