INOSITOL 1,3,4,6-TETRAKISPHOSPHATE MOBILIZES CALCIUM IN XENOPUS OOCYTES WITH HIGH POTENCY

Injection of Ins(1,3,4,6)P4 into Xenopus oocytes evoked Ca2+ -dependent membrane currents with a potency 5-10 times less than Ins(1,4,5)P3, whereas Ins(1,3,4)P3 and Ins(1,3,4,5,6)P5 were almost ineffective. Responses to Ins(1,3,4,6)P4 arose through liberation of intracellular Ca2+ and through entry of extracellular Ca2+. These results, together with the observation that Ins(1,3,4,6)P4 facilitated responses to Ins(1,4,5)P3, suggests that both of these compounds may act on the same intracellular receptors.