IN-VIVO MUTATION AT THE HUMAN HPRT LOCUS

被引：24
作者：
CARIELLO, NF
SKOPEK, TR
机构：
来源：
TRENDS IN GENETICS | 1993年 / 9卷 / 09期
关键词：
D O I：
10.1016/0168-9525(93)90251-C
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The molecular nature of mutations that arise in vivo at the human hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus can be determined A wide variety of such mutations can be detected, including large and small deletions, frameshift mutations and single-base substitutions, as well as alterations that cause aberrant mRNA splicing. Here, we review the available information on mutations at this locus.
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页码：322 / 326
页数：5
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