Genetic and epigenetic factors: Role in male infertility

被引：45
|
作者：
Shamsi, M. B. [1 ]
Kumar, K. [1 ]
Dada, R. [1 ]
机构：
[1] All India Inst Med Sci, Dept Anat, Lab Mol Reprod & Genet, New Delhi 29, India
来源：
INDIAN JOURNAL OF UROLOGY | 2011年 / 27卷 / 01期
关键词：
Azoospermia; cytogenetic; DNA damage; epigenetics; infertility; mtDNA; mRNA; oligozoospermia; Y chromosome;
D O I：
10.4103/0970-1591.78436
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Genetic factors contribute upto 15%-30% cases of male infertility. Formation of spermatozoa occurs in a sequential manner with mitotic, meiotic, and postmeiotic differentiation phases each of which is controlled by an intricate genetic program. Genes control a variety of physiologic processes, such as hypothalamus-pituitary-gonadal axis, germ cell development, and differentiation. In the era of assisted reproduction technology, it is important to understand the genetic basis of infertility to provide maximum adapted therapeutics and counseling to the couple.
引用
收藏
页码：110 / 120
页数：11
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