INDUCTION OF GIX ANTIGEN AND GROSS CELL-SURFACE ANTIGEN AFTER INFECTION BY ECOTROPIC AND XENOTROPIC MURINE LEUKEMIA VIRUSES INVITRO

被引：50

作者：

ODONNELL, PV ^{[1
]}

STOCKERT, E ^{[1
]}

机构：

[1] MEMORIAL SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA

来源：

JOURNAL OF VIROLOGY | 1976年 / 20卷 / 03期

关键词：

D O I：

10.1128/JVI.20.3.545-554.1976

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A number of ecotropic and xenotropic murine leukemia viruses were examined for their ability to induce the GIX antigen and Gross cell surface antigen (GCSA) in tissue culture [mouse embryo WM1511 clone III6A] fibroblasts. GIX appears to be a constituent of murine leukemia virus gp70; a molecular characterization of GCSA has not yet been reported. Antigen induction was measured by the ability of productively infected cells to absorb cytotoxic activity from the standard GIX- and GCSA-typing antisera. Cells infected by ecotropic viruses displayed 4 distinct phenotypes: GIX:+/GCSA++, GIX-/GCSA++, GIX++/GCSA+, and GIX-/GCSA+; cells infected by xenotropic viruses were GIX-/GCSA+ or GIX-/GCSA-. GIX induction appeared to be a type-specific property of some but not all Gross-AKR type ecotropic viruses. Differences in the degree of absorption of the GCSA antiserum by ecotropic virus- and xenotropic virus-infected cells indicated that GCSA may comprise multiple antigenic determinants.

引用

页码：545 / 554

页数：10

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