INDUCTION OF GIX ANTIGEN AND GROSS CELL-SURFACE ANTIGEN AFTER INFECTION BY ECOTROPIC AND XENOTROPIC MURINE LEUKEMIA VIRUSES INVITRO

被引：50

作者：

ODONNELL, PV ^{[1
]}

STOCKERT, E ^{[1
]}

机构：

[1] MEMORIAL SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA

来源：

JOURNAL OF VIROLOGY | 1976年 / 20卷 / 03期

关键词：

D O I：

10.1128/JVI.20.3.545-554.1976

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A number of ecotropic and xenotropic murine leukemia viruses were examined for their ability to induce the GIX antigen and Gross cell surface antigen (GCSA) in tissue culture [mouse embryo WM1511 clone III6A] fibroblasts. GIX appears to be a constituent of murine leukemia virus gp70; a molecular characterization of GCSA has not yet been reported. Antigen induction was measured by the ability of productively infected cells to absorb cytotoxic activity from the standard GIX- and GCSA-typing antisera. Cells infected by ecotropic viruses displayed 4 distinct phenotypes: GIX:+/GCSA++, GIX-/GCSA++, GIX++/GCSA+, and GIX-/GCSA+; cells infected by xenotropic viruses were GIX-/GCSA+ or GIX-/GCSA-. GIX induction appeared to be a type-specific property of some but not all Gross-AKR type ecotropic viruses. Differences in the degree of absorption of the GCSA antiserum by ecotropic virus- and xenotropic virus-infected cells indicated that GCSA may comprise multiple antigenic determinants.

引用

页码：545 / 554

页数：10

共 46 条

[1] CHARACTERIZATION OF MURINE SARCOMA VIRUS (KIRSTEN) TRANSFORMATION OF MOUSE AND HUMAN CELLS [J].

AARONSON, SA ;

WEAVER, CA .

JOURNAL OF GENERAL VIROLOGY, 1971, 13 (NOV) :245-&

[2] WILD-TYPE GROSS LEUKEMIA-VIRUS - CLASSIFICATION OF SOLUBLE ANTIGENS (GSA) [J].

AOKI, T ;

HERBERMAN, RB ;

JOHNSON, PA ;

LIU, M ;

STURM, MM .

JOURNAL OF VIROLOGY, 1972, 10 (06) :1208-1219

[3] G (GROSS) AND H-2 CELL-SURFACE ANTIGENS - LOCATION ON GROSS LEUKEMIA CELLS BY ELECTRON MICROSCOPY WITH VISUALLY LABELED ANTIBODY [J].

AOKI, T ;

BOYSE, EA ;

OLD, LJ ;

HARVEN, ED ;

HAMMERLING, U ;

WOOD, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 65 (03) :569-+

[4] DIVERSITY OF ENVELOPE ANTIGENS ON MURINE TYPE-C RNA VIRUSES [J].

AOKI, T ;

HUEBNER, RJ ;

CHANG, KSS ;

STURM, MM ;

LIU, M .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 52 (04) :1189-1197

[5]

ARMSTRONG D, 1970, Infection and Immunity, V1, P1

[6] PROPOSED NOMENCLATURE FOR VIRION PROTEINS OF ONCOGENIC RNA VIRUSES [J].

AUGUST, JT ;

BOLOGNESI, DP ;

FLEISSNER, E ;

GILDEN, RV ;

NOWINSKI, RC .

VIROLOGY, 1974, 60 (02) :595-600

[7] DISTINCT CLASS OF INDUCIBLE MURINE TYPE-C VIRUSES THAT REPLICATES IN RABBIT SIRC CELL LINE [J].

BENVENISTE, RE ;

LIEBER, MM ;

TODARO, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (03) :602-606

[8] EVOLUTION OF TYPE C VIRAL GENES - PRESERVATION OF ANCESTRAL MURINE TYPE C VIRAL SEQUENCES IN PIG CELLULAR DNA [J].

BENVENISTE, RE ;

TODARO, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :4090-4094

[9] MECHANISM OF INDUCTION OF RNA TUMOR-VIRUSES BY HALOGENATED PYRIMIDINES [J].

BESMER, P ;

SMOTKIN, D ;

HASELTINE, W ;

FAN, H ;

WILSON, AT ;

PASKIND, M ;

WEINBERG, R ;

BALTIMORE, D .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1974, 39 :1103-1107

[10] NUCLEIC-ACID HOMOLOGY OF MURINE XENOTROPIC TYPE C VIRUSES [J].

CALLAHAN, R ;

LIEBER, MM ;

TODARO, GJ .

JOURNAL OF VIROLOGY, 1975, 15 (06) :1378-1384

← 1 2 3 4 5 →