SYSTEMIC LIDOCAINE SILENCES ECTOPIC NEUROMA AND DRG DISCHARGE WITHOUT BLOCKING NERVE-CONDUCTION

被引：405

作者：

DEVOR, M ^{[1
]}

WALL, PD ^{[1
]}

CATALAN, N ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,CEREBRAL FUNCT GRP,LONDON WC1E 6BT,ENGLAND

来源：

PAIN | 1992年 / 48卷 / 02期

关键词：

ECTOPIC DISCHARGE; LIDOCAINE; LOCAL ANESTHETICS; NERVE INJURY; NEUROMA; NEUROPATHIC PAIN; PAIN;

D O I：

10.1016/0304-3959(92)90067-L

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Systemic application of lidocaine in rats suppressed ectopic impulse discharge generated both at sites of experimental nerve injury and in axotomized dorsal root ganglion (DRG) cells. ED50 for DRGs was significantly lower than for the injury site. Lidocaine doses effective at blocking ectopic discharge failed to block the initiation or propagation of impulses by electrical stimulation, and only minimally affected normal sensory receptors. This selectivity may account for the effectiveness of systemic local anesthetics and other drugs that share the same mechanism of action (notably certain anticonvulsants and antiarrhythmics), in the management of neuropathic paresthesias and pain. In addition, it may account for the prolonged analgesia sometimes obtained using regional local anesthetic block.

引用

页码：261 / 268

页数：8

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