HIV-1 PROTEASE CLEAVES ACTIN DURING ACUTE INFECTION OF HUMAN LYMPHOCYTES-T

被引:43
作者
ADAMS, LD [1 ]
TOMASSELLI, AG [1 ]
ROBBINS, P [1 ]
MOSS, B [1 ]
HEINRIKSON, RL [1 ]
机构
[1] NIAID,VIRAL DIS LAB,BETHESDA,MD 20892
关键词
D O I
10.1089/aid.1992.8.291
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.
引用
收藏
页码:291 / 295
页数:5
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