MILBEMYCIN SYNTHESIS - SYNTHESIS OF 6-BETA-HYDROXY-3,4-DIHYDROMILBEMYCIN-E

被引：12

作者：

KARIM, S ^{[1
]}

PARMEE, ER ^{[1
]}

THOMAS, EJ ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 20期

关键词：

MILBEMYCIN; ROBINSON ANNELATION; MACROCYCLISATION; FURAN OXIDATION; SPIROACETAL;

D O I：

10.1016/S0040-4039(00)79699-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydroxycyclohexanone (7), readily available via a Robinson annelation, is converted into the hydroxybutenolide (15), which is incorporated into a synthesis of 6-beta-hydroxymilbemycin E (28).

引用

页码：2269 / 2272

页数：4

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