A ROLE OF LYSOPHOSPHATIDYLCHOLINE IN GM3-DEPENDENT INHIBITION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AUTOPHOSPHORYLATION IN A431 PLASMA-MEMBRANES

被引：19

作者：

IGARASHI, Y ^{[1
]}

KITAMURA, K ^{[1
]}

ZHOU, QH ^{[1
]}

HAKOMORI, S ^{[1
]}

机构：

[1] UNIV WASHINGTON,SEATTLE,WA 98195

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80175-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

EGF-dependent receptor autophosphorylation (EDRA) in A431 plasma membrane was specifically stimulated by lysophospholipids having phosphorylcholine head group (e.g., lyso-phosphatidylcholine; lyso-PC), but not other lysophospholipids, in the absence of detergent. In contrast, GM3 specifically inhibited EDRA under the same experimental conditions in which lyso-PC stimulated EDRA. This GM3-dependent inhibition was more efficient in the absence (vs. presence) of a detergent (Triton X-100). These results indicate an essential role of lyso-PC in GM3-regulated EGF receptor functions. © 1990 Academic Press, Inc.

引用

页码：77 / 84

页数：8

共 15 条

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