PROPAFENONE KINETICS IN THE HORSE - COMPARATIVE-ANALYSIS OF COMPARTMENTAL AND NONCOMPARTMENTAL MODELS

被引：8

作者：

PUIGDEMONT, A ^{[1
]}

RIU, JL ^{[1
]}

GUITART, R ^{[1
]}

ARBOIX, M ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,FAC VET,DEPT FARMACOL,E-08193 BARCELONA,SPAIN

来源：

JOURNAL OF PHARMACOLOGICAL METHODS | 1990年 / 23卷 / 02期

关键词：

Compartmental and noncompartmental models; Horse; Pharmacokinetics; Propafenone;

D O I：

10.1016/0160-5402(90)90035-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.

引用

页码：79 / 85

页数：7

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