PROPAFENONE KINETICS IN THE HORSE - COMPARATIVE-ANALYSIS OF COMPARTMENTAL AND NONCOMPARTMENTAL MODELS

被引:8
|
作者
PUIGDEMONT, A [1 ]
RIU, JL [1 ]
GUITART, R [1 ]
ARBOIX, M [1 ]
机构
[1] UNIV AUTONOMA BARCELONA,FAC VET,DEPT FARMACOL,E-08193 BARCELONA,SPAIN
来源
JOURNAL OF PHARMACOLOGICAL METHODS | 1990年 / 23卷 / 02期
关键词
Compartmental and noncompartmental models; Horse; Pharmacokinetics; Propafenone;
D O I
10.1016/0160-5402(90)90035-J
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.
引用
收藏
页码:79 / 85
页数:7
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