MODEL STUDY ON THE BIOREDUCTION OF PARAQUAT, MPP+, AND ANALOGS - EVIDENCE AGAINST A REDOX CYCLING MECHANISM IN MPTP NEUROTOXICITY

被引：70
作者：
FRANK, DM
ARORA, PK
BLUMER, JL
SAYRE, LM
机构：
[1] CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA
[2] CASE WESTERN RESERVE UNIV, DEPT PEDIAT & PHARMACOL, CLEVELAND, OH 44106 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 147卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(87)80183-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1095 / 1104
页数：10
相关论文
共 66 条
[31]   DIFFERENCES IN THE METABOLISM OF MPTP IN THE RODENT AND PRIMATE PARALLEL DIFFERENCES IN SENSITIVITY TO ITS NEUROTOXIC EFFECTS [J].
JOHANNESSEN, JN ;
CHIUEH, CC ;
BURNS, RS ;
MARKEY, SP .
LIFE SCIENCES, 1985, 36 (03) :219-224
[32]   TOXIC DRUG EFFECTS ASSOCIATED WITH OXYGEN-METABOLISM - REDOX CYCLING AND LIPID-PEROXIDATION [J].
KAPPUS, H ;
SIES, H .
EXPERIENTIA, 1981, 37 (12) :1233-1241
[33]   MECHANISM OF DISMUTATION OF SUPEROXIDE PRODUCED DURING AUTOXIDATION OF MELANIN PIGMENTS [J].
KORYTOWSKI, W ;
HINTZ, P ;
SEALY, RC ;
KALYANARAMAN, B .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 131 (02) :659-665
[34]   INHIBITION OF MICROSOMAL ALDRIN EPOXIDATION BY DIQUAT AND SEVERAL RELATED BIPYRIDYLIUM COMPOUNDS [J].
KRIEGER, RI ;
LEE, PW ;
BLACK, A ;
FUKUTO, TR .
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1973, 9 (01) :1-3
[35]  
KRISHNA G, 1987, FED PROC, V46, P1152
[36]   GENERATION OF SUPEROXIDE ANION AS A SOURCE OF HYDROGEN-PEROXIDE IN A RECONSTITUTED MONO-OXYGENASE SYSTEM [J].
KUTHAN, H ;
TSUJI, H ;
GRAF, H ;
ULLRICH, V ;
WERRINGLOER, J ;
ESTABROOK, RW .
FEBS LETTERS, 1978, 91 (02) :343-345
[37]   CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].
LANGSTON, JW ;
BALLARD, P ;
TETRUD, JW ;
IRWIN, I .
SCIENCE, 1983, 219 (4587) :979-980
[38]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[39]  
LYLE RE, 1962, TETRAHEDRON LETT, P553
[40]  
Markey S. P., 1986, MPTP NEUROTOXIN PROD
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