MODEL STUDY ON THE BIOREDUCTION OF PARAQUAT, MPP+, AND ANALOGS - EVIDENCE AGAINST A REDOX CYCLING MECHANISM IN MPTP NEUROTOXICITY

被引：70
作者：
FRANK, DM
ARORA, PK
BLUMER, JL
SAYRE, LM
机构：
[1] CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA
[2] CASE WESTERN RESERVE UNIV, DEPT PEDIAT & PHARMACOL, CLEVELAND, OH 44106 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 147卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(87)80183-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1095 / 1104
页数：10
相关论文
共 66 条
[21]   SYNTHESIS, POLAROGRAPHY AND HERBICIDAL ACTIVITY OF QUATERNARY-SALTS OF 2-(4-PYRIDYL)-1,3,5-TRIAZINES, 5-(4-PYRIDYL)PYRIMIDINE, 2-(4-PYRIDYL)PYRIMIDINE AND RELATED-COMPOUNDS [J].
FISCHER, H ;
SUMMERS, LA .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (02) :333-336
[22]   ONE ELECTRON-TRANSFER PROPERTIES AND HERBICIDAL ACTIVITY OF DIQUATERNARY SALTS OF 2,4-DI-(4-PYRIDYL)-1,3,5-TRIAZINES [J].
FISCHER, H ;
SUMMERS, LA .
TETRAHEDRON, 1976, 32 (05) :615-618
[23]   ACTION OF PARAQUAT AND DIQUAT ON RESPIRATION OF LIVER CELL FRACTIONS [J].
GAGE, JC .
BIOCHEMICAL JOURNAL, 1968, 109 (05) :757-+
[24]  
Goodchild N. T., 1981, OXYGEN OXYRADICALS C, P645
[25]  
HARIK SI, 1987, J PHARMACOL EXP THER, V241, P669
[26]  
HEILLILA RE, 1985, NEUROSCI LETT, V59, P135
[27]  
Hirs C. H. W., 1967, METHOD ENZYMOL, V11, P325
[28]   STUDIES ON MECHANISM OF LUNG TOXICITY OF PARAQUAT - COMPARISON OF TISSUE DISTRIBUTION AND SOME BIOCHEMICAL PARAMETERS IN RATS AND RABBITS [J].
ILETT, KF ;
STRIPP, B ;
MENARD, RH ;
REID, WD ;
GILLETTE, JR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1974, 28 (02) :216-226
[29]   PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - UPTAKE OF THE METABOLITE N-METHYL-4-PHENYLPYRIDINE BY DOPAMINE NEURONS EXPLAINS SELECTIVE TOXICITY [J].
JAVITCH, JA ;
DAMATO, RJ ;
STRITTMATTER, SM ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) :2173-2177
[30]   1-METHYL-4-PHENYLPYRIDINE (MPP+) INDUCES OXIDATIVE STRESS IN THE RODENT [J].
JOHANNESSEN, JN ;
ADAMS, JD ;
SCHULLER, HM ;
BACON, JP ;
MARKEY, SP .
LIFE SCIENCES, 1986, 38 (08) :743-749
1234567