MODEL STUDY ON THE BIOREDUCTION OF PARAQUAT, MPP+, AND ANALOGS - EVIDENCE AGAINST A REDOX CYCLING MECHANISM IN MPTP NEUROTOXICITY

被引:70
作者
FRANK, DM
ARORA, PK
BLUMER, JL
SAYRE, LM
机构
[1] CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA
[2] CASE WESTERN RESERVE UNIV, DEPT PEDIAT & PHARMACOL, CLEVELAND, OH 44106 USA
关键词
D O I
10.1016/S0006-291X(87)80183-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1095 / 1104
页数:10
相关论文
共 66 条
[1]   USE OF ACETYLATED FERRICYTOCHROME-C FOR DETECTION OF SUPEROXIDE RADICALS PRODUCED IN BIOLOGICAL-MEMBRANES [J].
AZZI, A ;
MONTECUCCO, C ;
RICHTER, C .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 65 (02) :597-603
[2]   1-ELECTRON TRANSFER PROPERTIES OF DIQUATERNARY SALTS OF 2-(2-PYRIDYL)-QUINOLINE [J].
BLACK, AL ;
SUMMERS, LA .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1971, (12) :2271-&
[3]  
BLUMER JL, 1978, J BIOL CHEM, V253, P1159
[4]   1-METHYL-4-PHENYLPYRIDINE IS NEUROTOXIC TO THE NIGROSTRIATAL DOPAMINE PATHWAY [J].
BRADBURY, AJ ;
COSTALL, B ;
DOMENEY, AM ;
JENNER, P ;
KELLY, ME ;
MARSDEN, CD ;
NAYLOR, RJ .
NATURE, 1986, 319 (6048) :56-57
[5]   PARAQUAT-INDUCED ALTERATIONS OF PHOSPHOLIPIDS AND GSSG-RELEASE IN THE ISOLATED PERFUSED-RAT-LIVER, AND THE EFFECT OF SOD-ACTIVE COPPER-COMPLEXES [J].
BRIGELIUS, R ;
HASHEM, A ;
LENGFELDER, E .
BIOCHEMICAL PHARMACOLOGY, 1981, 30 (04) :349-354
[6]   MECHANISM OF PARAQUAT TOXICITY IN MICE AND RATS [J].
BUS, JS ;
CAGEN, SZ ;
OLGAARD, M ;
GIBSON, JE .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1976, 35 (03) :501-513
[7]   SUPEROXIDE-CATALYZED AND SINGLET OXYGEN-CATALYZED LIPID PEROXIDATION AS A POSSIBLE MECHANISM FOR PARAQUAT (METHYL VIOLOGEN) TOXICITY [J].
BUS, JS ;
GIBSON, JE ;
AUST, SD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 58 (03) :749-755
[8]   ELECTRON-SPIN RESONANCE STUDIES OF CHLOROQUINE MELANIN COMPLEXES [J].
BUSZMAN, E ;
KOPERA, M ;
WILCZOK, T .
BIOCHEMICAL PHARMACOLOGY, 1984, 33 (01) :7-11
[9]   EFFECTS OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE AND ITS METABOLITE 1-METHYL-4-PHENYLPYRIDINE ON ACETYLCHOLINE SYNTHESIS IN SYNAPTOSOMES FROM RAT FOREBRAIN [J].
CHEESEMAN, AJ ;
CLARK, JB .
JOURNAL OF NEUROCHEMISTRY, 1987, 48 (04) :1209-1214
[10]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578