CHEMOTHERAPY OF PANCREATIC-CANCER WITH THE MONOTERPENE PERILLYL ALCOHOL

被引：104

作者：

STARK, MJ ^{[1
]}

BURKE, YD ^{[1
]}

MCKINZIE, JH ^{[1
]}

AYOUBI, AS ^{[1
]}

CROWELL, PL ^{[1
]}

机构：

[1] INDIANA UNIV PURDUE UNIV,DEPT BIOL,INDIANAPOLIS,IN 46202

来源：

CANCER LETTERS | 1995年 / 96卷 / 01期

关键词：

MONOTERPENE; PANCREATIC NEOPLASM; PERILLYL ALCOHOL;

D O I：

10.1016/0304-3835(95)03912-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Perillyl alcohol has antitumor activity against rat mammary and liver cancer. Here, we report the chemotherapeutic effects of perillyl alcohol on pancreatic cancer. Perillyl alcohol reduced the growth of hamster pancreatic tumors to less than half that of controls (P < 0.025). Moreover, 16% of perillyl alcohol-treated pancreatic tumors completely regressed whereas no control tumors regressed (P < 0.05). Perillyl alcohol induced contact inhibition in cultured human pancreatic carcinoma cells and inhibited their anchorage-independent growth (P < 0.001). Thus, perillyl alcohol has antitumor activity against pancreatic carcinomas at non-toxic doses, and may be an effective chemotherapeutic agent for human pancreatic cancer.

引用

页码：15 / 21

页数：7

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