INTESTINAL EPITHELIAL-CELL DIFFERENTIATION - NEW INSIGHTS FROM MICE, FLIES AND NEMATODES

被引：68

作者：

SIMON, TC ^{[1
]}

GORDON, JI ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT MOLEC PHARMACOL & BIOCHEM,ST LOUIS,MO 63110

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0959-437X(95)80026-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Decisions commonly made during development that affect proliferation, cell fate specification, differentiation, migration, and death are made repeatedly in the mouse small intestinal epithelium throughout adulthood. The results of these decisions are a stratification of proliferation, differentiation, and death along the mouse small intestine's crypt/villus axis. Recent genetic studies in Caenorhabditis elegans and Drosophila melanogaster have identified factors involved in determining cell fate and differentiation in gut endoderm. The stem cell hierarchy of the adult mouse intestinal epithelium makes it ideally suited for using chimeric animals to examine the functions of homologs of these lower eukaryotic (and other) proteins.

引用

页码：577 / 586

页数：10

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