Protective role of Nigella sativa against experimentally induced type-II diabetic nuclear damage in Wistar rats

被引：5

作者：

Sheikh, T. J. ^{[1
]}

Joshi, D. V. ^{[1
]}

Patel, B. J. ^{[1
]}

Modi, C. M. ^{[1
]}

机构：

[1] SD Agr Univ, Dept Vet Pathol, Coll Vet Sci & AH, Sardar Krushinagar 385506, Gujarat, India

来源：

VETERINARY WORLD | 2013年 / 6卷 / 09期

关键词：

antioxidant; diabetes; micronucleus test; Nigella sativa; plant extract;

D O I：

10.14202/vetworld.2013.698-702

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Aim: To identify the anti-mutagenic effect of Nigella sativa on the experimentally induced chronic diabetes (type -II) in Wistar rats. Materials and Methods: The anti-mutagenic effect was evaluated in Nigella sativa treated diabetic rats against the streptozotocin -nicotinamide (STZ-NA) (at a dose rate of 45-110 i. p mg/kg b. wt for 90 days) induced type-II diabetes mellitus using bone marrow micronucleus tests. The antioxidant status was tested by estimating the serum levels of lipid peroxidation and superoxide dismutase. Results: Our results indicated that diabetic rats treated with Nigella sativa decreased the frequency of micronuclei in the erythrocytes of bone marrow (P < 0.05) and enhanced the antioxidant status (P < 0.05) in the treated diabetic rats as compared to controls. Conclusion: The observations indicated that the diabetic patients are more prone to cell mutations which are related to the level of cellular oxidative status and it could be reduced by Nigella sativa.

引用

页码：698 / 702

页数：5

共 23 条

[1]

Al-Mayah K.S., 2012, MED J BABYLON, V9, P140

[2]

ALAWADI F, 1991, DIABETES RES CLIN EX, V18, P163

[3] Diagnosis and Classification of Diabetes Mellitus [J].

DIABETES CARE, 2010, 33 :S62-S69

[4] ROLE OF OXIDATIVE STRESS IN DEVELOPMENT OF COMPLICATIONS IN DIABETES [J].

BAYNES, JW .

DIABETES, 1991, 40 (04) :405-412

[5] Induction of chromosome aberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure [J].

Chauhan, LKS ;

Pant, N ;

Gupta, SK ;

Srivastava, SP .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2000, 465 (1-2) :123-129

[6] Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients [J].

Garcia-Ramirez, M. ;

Francisco, G. ;

Garcia-Arumi, E. ;

Hernandez, C. ;

Martinez, R. ;

Andreu, A. L. ;

Simo, R. .

DIABETES & METABOLISM, 2008, 34 (02) :117-124

[7] Chronic diseases 2 - Scaling up interventions for chronic disease prevention: the evidence [J].

Gaziano, Thomas A. ;

Galea, Gauden ;

Reddy, K. Srinath .

LANCET, 2007, 370 (9603) :1939-1946

[8] The Effects of Combined Treatment of Antioxidants on the Liver Injury in STZ Diabetic Rats [J].

Gezginci-Oktayoglu, Selda ;

Basaraner, Hasan ;

Yanardag, Refiye ;

Bolkent, Sehnaz .

DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (03) :538-546

[9] MICRONUCLEUS TEST AS PART OF A SHORT-TERM MUTAGENICITY TEST PROGRAM FOR THE PREDICTION OF CARCINOGENICITY EVALUATED BY 143 AGENTS TESTED [J].

JENSSEN, D ;

RAMEL, C .

MUTATION RESEARCH, 1980, 75 (02) :191-202

[10] Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy [J].

Kanter, Mehmet .

NEUROCHEMICAL RESEARCH, 2008, 33 (01) :87-96

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