RENAL SYMPATHETIC-NERVE ACTIVITY IS INCREASED IN OBESE ZUCKER RATS

被引:91
|
作者
MORGAN, DA
ANDERSON, EA
MARK, AL
机构
[1] UNIV IOWA, COLL MED,DEPT INTERNAL MED,DIV CARDIOVASC, IOWA CITY, IA 52242 USA
[2] UNIV IOWA, COLL MED,CTR CARDIOVASC, IOWA CITY, IA 52242 USA
[3] UNIV IOWA, COLL MED,DEPT ANESTHESIA, IOWA CITY, IA 52242 USA
[4] VET ADM MED CTR, IOWA CITY, IA USA
关键词
KIDNEY; SYMPATHETIC NERVOUS SYSTEM; OBESITY; RATS; ZUCKER; SODIUM; DIETARY;
D O I
10.1161/01.HYP.25.4.834
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
A low level of sympathetic nerve activity (SNA) to brown adipose tissue has been found in genetically obese Zucker rats and may promote obesity through decreased thermogenesis. In contrast, acquired obesity is reportedly associated with increased SNA. To determine whether low SNA levels in obese Zucker rats extend to the kidney, we compared baseline levels of renal SNA in obese and lean conscious unrestrained Zucker rats fed for 2 weeks on low salt (0.4% NaCl) and high salt (8.0% NaCl) diets. Baseline renal SNA was calculated from multifiber recordings obtained before death under conscious, resting conditions and after death. Body weight averaged 490+/-12 g (mean+/-SEM) in obese rats (n=17) and 339+/-7 g in lean rats (n=19). Mean arterial pressure did not differ in obese and lean Zucker rats fed the low salt diet. However, on the high salt diet, mean arterial pressure was significantly higher in obese rats (n=8) than in lean rats (n=9) (113+/-3 and 101+/-3 mm Hg, respectively; P<.05). Baseline renal SNA was approximately 2 to 2.5 times higher (P<.05) in obese rats than in lean rats in all groups. These studies suggest that obese Zucker rats have heightened levels of SNA to the kidney in contrast to reduced SNA to brown adipose tissue.
引用
收藏
页码:834 / 838
页数:5
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