ISCHEMIC STRESS INDUCES DEPOSITION OF AMYLOID-BETA IMMUNOREACTIVITY IN HUMAN BRAIN

被引:142
|
作者
JENDROSKA, K
POEWE, W
DANIEL, SE
PLUESS, J
IWERSSENSCHMIDT, H
PAULSEN, J
BARTHEL, S
SCHELOSKY, L
CERVOSNAVARRO, J
DEARMOND, SJ
机构
[1] BENJAMIN FRANKLIN HOSP,INST NEUROPATHOL,D-12203 BERLIN,GERMANY
[2] INST NEUROL,PARKINSONS DIS SOC,BRAIN BANK,LONDON WC1N 1PJ,ENGLAND
[3] UNIV CALIF SAN FRANCISCO,DEPT PATHOL,NEUROPATHOL UNIT,SAN FRANCISCO,CA 94143
关键词
AMYLOID BETA PROTEIN; ISCHEMIA; ALZHEIMERS DISEASE; HISTOBLOT;
D O I
10.1007/bf00294806
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid beta protein (A beta). We investigated brains of 131 subjects (ages 25-94 years, mean 72 years). Three distribution patterns of A beta immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated ''stress-induced deposits'' (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
引用
收藏
页码:461 / 466
页数:6
相关论文
共 50 条
  • [21] Serum albumin and beta-amyloid deposition in the human brain
    Kim, Jee Wook
    Byun, Min Soo
    Lee, Jun Ho
    Yi, Dahyun
    Jeon, So Yeon
    Sohn, Bo Kyung
    Lee, Jun-Young
    Shin, Seong A.
    Kim, Yu Kyeong
    Kang, Koung Mi
    Sohn, Chul-Ho
    Lee, Dong Young
    NEUROLOGY, 2020, 95 (07) : E815 - E826
  • [22] Amyloid-beta stress test in patients with Alzheimer disease
    Fiala, Milan
    Zaghi, Justin
    Liu, Philip T.
    Rosenthal, Mark
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2008, 67 (05): : 493 - 493
  • [23] Amyloid-beta stress test in patients with Alzheimer disease
    Fiala, Milan
    Zaghi, Justin
    Liu, Philip T.
    Rosenthal, Mark
    FASEB JOURNAL, 2008, 22
  • [25] Immunoreactivity of the amino-terminal portion of the amyloid-beta precursor protein in the nucleolus
    Okamoto, Masaji
    NEUROSCIENCE LETTERS, 2012, 521 (01) : 82 - 87
  • [26] Effect of the aggregation state of amyloid-beta (25-35) on the brain oxidative stress in vivo
    Kozina, Anna
    Herbert-Alonso, Goethe
    Diaz, Alfonso
    Flores, Gonzalo
    Guevara, Jorge
    PLOS ONE, 2024, 19 (10):
  • [27] Human arachnoid membrane: active transport of amyloid-beta
    Deborah M Grzybowski
    Amy C Long
    Clint W Allred
    David W Holman
    John E Donahue
    Shelley A Glimcher
    Conrad Johanson
    Edward Stopa
    Martin Lubow
    Cerebrospinal Fluid Research, 6 (Suppl 1):
  • [28] Quantification of amyloid-beta in mouse and human eye tissues
    Parthasarathy, Rajni
    Fautsch, Michael P.
    Pepperberg, David R.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [29] Human secreted tau increases amyloid-beta production
    Bright, Jessica
    Hussain, Sami
    Dang, Vu
    Wright, Sarah
    Cooper, Bonnie
    Byun, Tony
    Ramos, Carla
    Singh, Andrew
    Parry, Graham
    Stagliano, Nancy
    Griswold-Prenner, Irene
    NEUROBIOLOGY OF AGING, 2015, 36 (02) : 693 - 709
  • [30] Nanogold induces anti-inflammation against oxidative stress induced in human neural stem cells exposed to amyloid-beta peptide
    Chiang, Ming-Chang
    Nicol, Christopher J. B.
    Lin, Chien-Hung
    Chen, Shiang-Jiuun
    Yen, Chiahui
    Huang, Rong-Nan
    NEUROCHEMISTRY INTERNATIONAL, 2021, 145