HORMONAL-REGULATION OF ADIPOSE DIFFERENTIATION

被引：31

作者：

AILHAUD, G

GRIMALDI, P

NEGREL, R

机构：

[1] Center for Biochemistry (CNRS UMR 134), University of Nice-Sophia Antipolis, Faculty of Sciences, 06108 Nice 2, Parc Valrose

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 03期

关键词：

D O I：

10.1016/1043-2760(94)90095-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose differentiation is a multistep process with the following sequence: adipoblasts --> preadipocytes --> adipocytes. Adipogenic agents are only involved in the terminal differentiation of preadipocytes to adipocytes by means of circulating hormones (growth hormone, glucocorticoids, or triiodothyronine) and locally produced hormones (prostacyclin). Fatty acids also behave as hormones and act as transcriptional regulators of lipid-related genes. Once differentiated, adipocytes become secretory cells able to synthetize and release an impressive number of peptide and nonpeptide compounds, suggesting a potential link between excess of adipose tissue mass and various physiopathphysiologic consequences.

引用

页码：132 / 136

页数：5

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