QUANTITATION OF PERFLUOROCARBON BLOOD SUBSTITUTES IN TISSUES USING F-19 MAGNETIC-RESONANCE SPECTROSCOPY

被引：9
|
作者：
PRATT, RG [1 ]
THOMAS, SR [1 ]
MILLARD, RW [1 ]
SAMARATUNGA, RC [1 ]
NASEEM, MH [1 ]
机构：
[1] UNIV CINCINNATI,COLL MED,DEPT PHARMACOL & CELL BIOPHYS,CINCINNATI,OH 45267
来源：
BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期
关键词：
D O I：
10.3109/10731199209119742
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
F-19 Magnetic Resonance Spectroscopy (MRS) has been used to quantitate the biodistribution of perfluorocarbon (PFC) blood substitutes in porcine tissues following intraperitoneal administration of a 20% w/v perfluorotributylamine (FC-43) based emulsion. PFC tissue concentrations were determined for spleen, liver and lung tissues from juvenile pigs ranging in weight from 12 to 15 kg. Typical average values (mmoles FC-43/gam tissue) ranged from 0.23 - 0.39 for spleen; 0.09 - 0.13 for liver; and 0.09 - 0.12 for lung. A description of this spectroscopy based quantitation technique will be presented. F-19 MRS is a specific, rapid, and accurate method for measurement of PFC tissue concentrations,
引用
收藏
页码：921 / 924
页数：4
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