Solvent and Catalyst Free, Regioselective alpha-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol

被引：14
作者：
Vekariya, Rajesh H. [1 ]
Panchal, Shyamali N. [1 ]
Patel, Kinjal D. [1 ]
Patel, Hitesh D. [1 ]
机构：
[1] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad, Gujarat, India
来源：
CURRENT MICROWAVE CHEMISTRY | 2015年 / 2卷 / 01期
关键词：
alpha-bromination; catalyst free; efficient protocol green bromination; microwave irradiation; N-bromosuccinimide; regeneration; regioselectivity; solvent free;
D O I：
10.2174/221333560201150212111506
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An exceptionally efficient, environmentally safe and economic method has been developed for regioselective alpha-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide ( NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/ NaBrO3 in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.
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收藏
页码：61 / 68
页数：8
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