Molecular Biomarkers in Schizophrenia - Implications for Clinical Practice

被引：0

作者：

Lee, Jimmy ^{[1
,2
]}

Chong, Siow-Ann ^{[1
]}

机构：

[1] Woodbridge Hosp, Inst Mental Hlth, Div Res, Singapore, Singapore

[2] Duke NUS Grad Med Sch, Singapore, Singapore

来源：

CURRENT PSYCHIATRY REVIEWS | 2010年 / 6卷 / 02期

关键词：

Schizophrenia; biomarkers; genomics; epigenomics; proteomics; lipidomics;

D O I：

10.2174/157340010791196475

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Schizophrenia is a serious mental illness and clinical diagnosis over the past century had been based on recognition of a certain pattern of thinking, perception and behavior. Although mostly people accept that the disease is a complex phenotypic presentation with a strong hereditary predisposition, the exact pathophysiology of schizophrenia has not been clearly elucidated. Rapid advancements in genomics, epigenomics, transcriptomics, proteomics and lipidomics had been made in the search for molecular biomarkers in schizophrenia which could potentially aid clinicians in understanding and subtyping psychosis. It could assist in diagnosis and selection of appropriate antipsychotic therapy, it also provides early indicators of clinical response. In this review, we discuss relevant literature with regards to these advancements, their challenges and their potential clinical impact.

引用

页码：114 / 121

页数：8

共 101 条

[81] Neuregulin 1 and susceptibility to schizophrenia [J].

Stefansson, H ;

Sigurdsson, E ;

Steinthorsdottir, V ;

Bjornsdottir, S ;

Sigmundsson, T ;

Ghosh, S ;

Brynjolfsson, J ;

Gunnarsdottir, S ;

Ivarsson, O ;

Chou, TT ;

Hjaltason, O ;

Birgisdottir, B ;

Jonsson, H ;

Gudnadottir, VG ;

Gudmundsdottir, E ;

Bjornsson, A ;

Ingvarsson, B ;

Ingason, A ;

Sigfusson, S ;

Hardardottir, H ;

Harvey, RP ;

Lai, D ;

Zhou, MD ;

Brunner, D ;

Mutel, V ;

Gonzalo, A ;

Lemke, G ;

Sainz, J ;

Johannesson, G ;

Andresson, T ;

Gudbjartsson, D ;

Manolescu, A ;

Frigge, ML ;

Gurney, ME ;

Kong, A ;

Gulcher, JR ;

Petursson, H ;

Stefansson, K .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) :877-892

[82] Large recurrent microdeletions associated with schizophrenia [J].

Stefansson, Hreinn ;

Rujescu, Dan ;

Cichon, Sven ;

Pietilainen, Olli P. H. ;

Ingason, Andres ;

Steinberg, Stacy ;

Fossdal, Ragnheidur ;

Sigurdsson, Engilbert ;

Sigmundsson, Thordur ;

Buizer-Voskamp, Jacobine E. ;

Hansen, Thomas ;

Jakobsen, Klaus D. ;

Muglia, Pierandrea ;

Francks, Clyde ;

Matthews, Paul M. ;

Gylfason, Arnaldur ;

Halldorsson, Bjarni V. ;

Gudbjartsson, Daniel ;

Thorgeirsson, Thorgeir E. ;

Sigurdsson, Asgeir ;

Jonasdottir, Adalbjorg ;

Jonasdottir, Aslaug ;

Bjornsson, Asgeir ;

Mattiasdottir, Sigurborg ;

Blondal, Thorarinn ;

Haraldsson, Magnus ;

Magnusdottir, Brynja B. ;

Giegling, Ina ;

Moeller, Hans-Juergen ;

Hartmann, Annette ;

Shianna, Kevin V. ;

Ge, Dongliang ;

Need, Anna C. ;

Crombie, Caroline ;

Fraser, Gillian ;

Walker, Nicholas ;

Lonnqvist, Jouko ;

Suvisaari, Jaana ;

Tuulio-Henriksson, Annamarie ;

Paunio, Tiina ;

Toulopoulou, Timi ;

Bramon, Elvira ;

Di Forti, Marta ;

Murray, Robin ;

Ruggeri, Mirella ;

Vassos, Evangelos ;

Tosato, Sarah ;

Walshe, Muriel ;

Li, Tao ;

Vasilescu, Catalina .

NATURE, 2008, 455 (7210) :232-U61

[83] Common variants conferring risk of schizophrenia [J].

Stefansson, Hreinn ;

Ophoff, Roel A. ;

Steinberg, Stacy ;

Andreassen, Ole A. ;

Cichon, Sven ;

Rujescu, Dan ;

Werge, Thomas ;

Pietilainen, Olli P. H. ;

Mors, Ole ;

Mortensen, Preben B. ;

Sigurdsson, Engilbert ;

Gustafsson, Omar ;

Nyegaard, Mette ;

Tuulio-Henriksson, Annamari ;

Ingason, Andres ;

Hansen, Thomas ;

Suvisaari, Jaana ;

Lonnqvist, Jouko ;

Paunio, Tiina ;

Borglum, Anders D. ;

Hartmann, Annette ;

Fink-Jensen, Anders ;

Nordentoft, Merete ;

Hougaard, David ;

Norgaard-Pedersen, Bent ;

Bottcher, Yvonne ;

Olesen, Jes ;

Breuer, Rene ;

Moeller, Hans-Jurgen ;

Giegling, Ina ;

Rasmussen, Henrik B. ;

Timm, Sally ;

Mattheisen, Manuel ;

Bitter, Istvan ;

Rethelyi, Janos M. ;

Magnusdottir, Brynja B. ;

Sigmundsson, Thordur ;

Olason, Pall ;

Mason, Gisli ;

Gulcher, Jeffrey R. ;

Haraldsson, Magnus ;

Fossdal, Ragnheidur ;

Thorgeirsson, Thorgeir E. ;

Thorsteinsdottir, Unnur ;

Ruggeri, Mirella ;

Tosato, Sarah ;

Franke, Barbara ;

Strengman, Eric ;

Kiemeney, Lambertus A. ;

Melle, Ingrid .

NATURE, 2009, 460 (7256) :744-U99

[84] Rare chromosomal deletions and duplications increase risk of schizophrenia [J].

Stone, Jennifer L. ;

O'Donovan, Michael C. ;

Gurling, Hugh ;

Kirov, George K. ;

Blackwood, Douglas H. R. ;

Corvin, Aiden ;

Craddock, Nick J. ;

Gill, Michael ;

Hultman, Christina M. ;

Lichtenstein, Paul ;

McQuillin, Andrew ;

Pato, Carlos N. ;

Ruderfer, Douglas M. ;

Owen, Michael J. ;

St Clair, David ;

Sullivan, Patrick F. ;

Sklar, Pamela ;

Purcell, Shaun M. ;

Scolnick, E. M. ;

Holmans, P. A. ;

Georgieva, L. ;

Nikolov, I. ;

Norton, N. ;

Williams, H. ;

Williams, N. M. ;

Toncheva, D. ;

Milanova, V. ;

Thelander, E. F. ;

Morris, D. W. ;

O'Dushlaine, C. T. ;

Kenny, E. ;

Waddington, J. L. ;

Choudhury, K. ;

Datta, S. ;

Pimm, J. ;

Thirumalai, S. ;

Puri, V. ;

Krasucki, R. ;

Lawrence, J. ;

Quested, D. ;

Bass, N. ;

Curtis, D. ;

Crombie, C. ;

Fraser, G. ;

Kwan, S. L. ;

Muir, W. J. ;

McGhee, K. A. ;

Pickard, B. ;

Malloy, P. ;

Maclean, A. W. .

NATURE, 2008, 455 (7210) :237-241

[85] Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited [J].

Strous, Rael D. ;

Shoenfeld, Yehuda .

JOURNAL OF AUTOIMMUNITY, 2006, 27 (02) :71-80

[86] Genomewide association for schizophrenia in the CATIE study: results of stage 1 [J].

Sullivan, P. F. ;

Lin, D. ;

Tzeng, J-Y ;

van den Oord, E. ;

Perkins, D. ;

Stroup, T. S. ;

Wagner, M. ;

Lee, S. ;

Wright, F. A. ;

Zou, F. ;

Liu, W. ;

Downing, A. M. ;

Lieberman, J. ;

Close, S. L. .

MOLECULAR PSYCHIATRY, 2008, 13 (06) :570-584

[87] Evaluating the comparability of gene expression in blood and brain [J].

Sullivan, PF ;

Fan, C ;

Perou, CM .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (03) :261-268

[88] The-141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients [J].

Suzuki, A ;

Kondo, T ;

Mahara, K ;

Yasui-Furukori, N ;

Ishida, M ;

Furukori, H ;

Kaneko, S ;

Inoue, Y ;

Otani, K .

PHARMACOGENETICS, 2001, 11 (06) :545-550

[89] Increased phospholipase A2 activity in schizophrenia with absent response to niacin [J].

Tavares, H ;

Yacubian, J ;

Talib, LL ;

Barbosa, NR ;

Gattaz, WF .

SCHIZOPHRENIA RESEARCH, 2003, 61 (01) :1-6

[90]

Templeman Lucy A, 2005, Pharmacogenet Genomics, V15, P195, DOI 10.1097/01213011-200504000-00002

← 2 3 4 5 6 7 8 9 10 11 →