SYNTHESIS OF N-SUBSTITUTED 7-BETA-DIPRENORPHINE DERIVATIVES

被引：17
|
作者：
MARTON, J
MIKLOS, S
HOSZTAFI, S
MAKLEIT, S
机构：
[1] ALKALOIDA CHEM CO LTD,H-4440 TISZAVASVARI,HUNGARY
[2] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY
来源：
SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 06期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1080/00397919508013419
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The separation of thevinone (2a) and beta-thevinone (2b), as well as that of dihydrothevinone (3a) and beta-dihydrothevinone (3b) was accomplished. By the application of various procedures numerous new N-substituted Diprenorphine analogues (8a-f) with 7R absolute configuration were synthesized. Detailed pharmacological investigation of the prepared compounds may contribute to a better understanding of the structure-activity relationship of morphine alkaloids.
引用
收藏
页码：829 / 848
页数：20
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