SYNTHESIS OF N-SUBSTITUTED 7-BETA-DIPRENORPHINE DERIVATIVES

被引：17

作者：

MARTON, J

MIKLOS, S

HOSZTAFI, S

MAKLEIT, S

机构：

[1] ALKALOIDA CHEM CO LTD,H-4440 TISZAVASVARI,HUNGARY

[2] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY

来源：

SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1080/00397919508013419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The separation of thevinone (2a) and beta-thevinone (2b), as well as that of dihydrothevinone (3a) and beta-dihydrothevinone (3b) was accomplished. By the application of various procedures numerous new N-substituted Diprenorphine analogues (8a-f) with 7R absolute configuration were synthesized. Detailed pharmacological investigation of the prepared compounds may contribute to a better understanding of the structure-activity relationship of morphine alkaloids.

引用

页码：829 / 848

页数：20

共 17 条

[1] BENTLEY KW, 1963, P CHEM SOC LONDON, P220
[2] THE MORPHINE-THEBAINE GROUP OF ALKALOIDS .6. THE CONDENSATION OF THEBAINE WITH DIENOPHILS
BENTLEY, KW
THOMAS, AF
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1956, (JUN): : 1863 - 1867
[3] NOVEL ANALGESICS AND MOLECULAR REARRANGEMENTS IN MORPHINE-THEBAINE GROUP .I. KETONES DERIVED FROM 6,14-ENDO-ETHENOTETRAHYDROTHEBAINE
BENTLEY, KW
HARDY, DG
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (13) : 3267 - &
[4] PREPARATION OF 7-(1,3,4-OXADIAZOLYL)-6,14-ENDO-ETHENO-6,7,8,14-TETRAHYDROTHEBAINES AND RELATED-COMPOUNDS AS POTENTIAL ANALGESICS
BENTLEY, KW
BURTON, M
UFF, BC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (10) : 1276 - 1280
[5] NOVEL ANALGESICS AND MOLECULAR REARRANGEMENTS IN MORPHINE-THEBAINE GROUP .2. ALCOHOLS DERIVED FROM 6,14-ENDO-ETHENO- AND 6,14-ENDO-ETHANOTETRAHYDROTHEBAINE
BENTLEY, KW
HARDY, DG
MEEK, B
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (13) : 3273 - &
[6] NOVEL ANALGESICS AND MOLECULAR REARRANGEMENTS IN MORPHINE-THEBAINE GROUP .6. BASE-CATALYZED REARRANGEMENTS IN 6,14-ENDO-ETHENOTETRAHYDROTHEBAINE SERIES
BENTLEY, KW
HARDY, DG
CROCKER, HP
HADDLESEY, DI
MAYOR, PA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (13) : 3312 - +
[7] BENTLEY KW, 1971, MANSKE, V8, P75
[8] Bentley KW, 1968, Br. Patent, Patent No. 1136214
[9] Casy A. F., 1986, OPIOID ANALGESICS CH
[10] NUCLEAR MAGNETIC RESONANCE STUDIES IN 6,14-ENDO-ETHENOTETRAHYDROTHEBAINE SERIES
FULMOR, W
LANCASTER, JE
MORTON, GO
BROWN, JJ
HOWELL, CF
NORA, CT
HARDY, RA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (13) : 3322 - +

← 1 2 →