PROLIFERATIVE ACTIVITY AS A PROGNOSTIC FACTOR IN BORRMANN TYPE-4 GASTRIC-CARCINOMA

被引：26

作者：

KAKEJI, Y ^{[1
]}

MAEHARA, Y ^{[1
]}

ADACHI, Y ^{[1
]}

BABA, H ^{[1
]}

MORI, M ^{[1
]}

FURUSAWA, M ^{[1
]}

SUGIMACHI, K ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT SURG 2,FUKUOKA 812,JAPAN

来源：

BRITISH JOURNAL OF CANCER | 1994年 / 69卷 / 04期

关键词：

D O I：

10.1038/bjc.1994.141

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P<0.01), and these patients had a lower survival rate (P<0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P<0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients' prognosis in cases of Borrmann type 4 gastric carcinoma.

引用

页码：749 / 753

页数：5

共 27 条

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[2]

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