Synthesis and Screening for Analgesic and Anti-inflammatory Activities of Some Novel Amino Acid-containing Bicyclo Compounds

Diazabicyclo[4.3.1] decane derivatives are well known opioid receptor ligands, hence, we have developed a novel and simple method for the synthesis of 3, 4-diphenyl-2,5-diaza-bicyclo[4.3.1] deca-1(9), 2,4,6( 10), 7-pentaene8- carbonyl chloride derivatives containing amino acid moieties. The compounds were structurally confirmed with the help of TLC, IR, NMR, and LCMS spectra. All the title compounds were screened for analgesic activity by using the tail-flick method and for anti-inflammatory activity by using the carrageenan-induced paw edema method using diclofenac sodium as a standard.