The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas

被引：38

作者：

Boender, Arjen J. ^{[1
]}

van Gestel, Margriet A. ^{[1
]}

Garner, Keith M. ^{[1
]}

Luijendijk, Mieneke C. M. ^{[1
]}

Adan, Roger A. H. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands

来源：

PHYSIOLOGICAL REPORTS | 2014年 / 2卷 / 07期

关键词：

AAV technology; arcuate nucleus; GWAS; Negr1; ventromedial hypothalamus;

D O I：

10.14814/phy2.12083

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our results provide further support for a role of hypothalamic expressed Negr1 in the regulation of energy balance.

引用

页数：9

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