Screening of microRNAs as possible biomarkers in abdominal aortic aneurysm

被引：0
|
作者：
Plana, E. [1 ,2 ]
Galvez, L. [1 ]
Medina, P. [2 ]
Navarro, S. [2 ]
Miralles, M. [1 ,2 ]
机构：
[1] Hosp Univ & Politecn La Fe, Serv Angiol & Cirugia Vasc, Valencia, Spain
[2] Inst Invest Sanit La Fe, Grp Acreditado Invest Hemostasia Trombosis Arteri, Valencia, Spain
来源：
ANGIOLOGIA | 2018年 / 70卷 / 01期
关键词：
miRs; Aneurysm; Biomarkers;
D O I：
10.1016/j.angio.2017.09.001
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Introduction: MicroRNAs (miRs) are small RNA molecules that are involved in several biological processes. Due to their stability and their presence in biological fluids, several studies over the last few years have focused on the use of miRs as biomarkers of different pathologies. Objective: Selection of a group of miRs candidates to be validated as potential biomarkers ofabdominal aortic aneurysm (AAA). Material and methods: A total of 179 miRs were quantified in 7 patients with AAA and in 7 healthy donors, using predesigned panels based on RT-qPCR technology. Results: A total of 10 miRs, dysregulated in patients, were selected as good candidates for studying them as biomarkers. It has been observed that most of these miRs participate in several biological processes related to the formation and development of AAAs. Conclusion: Additional, as well as validation, studies are needed, but some of these miRs could be non-invasive AAA biomarkers. (c) 2017 SEACV. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：13 / 18
页数：6
相关论文
共 50 条
  • [21] Ultrasoud Screening in Abdominal Aortic Aneurysm - Numbers, Data, Facts
    Hyhlik-Duerr, A.
    Debus, S.
    Eckstein, H. -H.
    Lang, W.
    Schmitz-Rixen, T.
    Boeckler, D.
    ZENTRALBLATT FUR CHIRURGIE, 2010, 135 (05): : 403 - 408
  • [22] Abdominal Aortic Aneurysm in Marfan Syndrome: Time for Screening Guidelines?
    Hagerty, Tracy
    Geraghty, Patrick
    Braverman, Alan C.
    CIRCULATION, 2015, 132
  • [23] Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
    Ferreira de Araujo, Neire Niara
    Lin-Wang, Hui Tzu
    Germano, Juliana de Freitas
    Farsky, Pedro Silvio
    Feldman, Andre
    Rossi, Fabio Henrique
    Izukawa, Nilo Mitsuru
    Higuchi, Maria de Lourdes
    Savioli Neto, Felicio
    Hirata, Mario Hiroyuki
    Bertolami, Marcelo Chiara
    PLOS ONE, 2019, 14 (09):
  • [24] Identification and Evaluation of Blood-Based Biomarkers for Abdominal Aortic Aneurysm
    Li, Ben
    Khan, Hamzah
    Shaikh, Farah
    Zamzam, Abdelrahman
    Abdin, Rawand
    Qadura, Mohammad
    JOURNAL OF PROTEOME RESEARCH, 2024, 23 (06) : 2279 - 2287
  • [25] Abdominal aortic aneurysm
    Skow, Glenn
    JOURNAL OF MENS HEALTH, 2011, 8 (04) : 306 - 312
  • [26] Abdominal Aortic Aneurysm
    Hong, You Sun
    JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, 2009, 52 (10): : 1020 - 1029
  • [27] Abdominal aortic aneurysm
    Brevetti, Gregorio
    Laurenzano, Eugenio
    De Maio, Julieta Isabel
    Chiariello, Massimo
    GIORNALE ITALIANO DI CARDIOLOGIA, 2007, 8 (09) : 543 - 551
  • [28] Identifying and Validating Novel Biomarkers and Potential Therapeutic Agents for Abdominal Aortic Aneurysm
    Tang, Hanfei
    Tang, Xiao
    Cai, Liang
    Xue, Song
    Fang, Chao
    Fu, Weiguo
    Guo, Daqiao
    CIRCULATION RESEARCH, 2020, 127 (12) : E274 - E274
  • [29] Current Prognostic Biomarkers for Abdominal Aortic Aneurysm: A Comprehensive Scoping Review of the Literature
    Khan, Hamzah
    Abu-Raisi, Mohamed
    Feasson, Manon
    Shaikh, Farah
    Saposnik, Gustavo
    Mamdani, Muhammad
    Qadura, Mohammad
    BIOMOLECULES, 2024, 14 (06)
  • [30] Benefit, Risks and Cost-Effectiveness of Screening for Abdominal Aortic Aneurysm
    Schmidt, T.
    Muehlberger, N.
    Chemelli-Steingruber, I. E.
    Strasak, A.
    Kofler, B.
    Chemelli, A.
    Siebert, U.
    ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2010, 182 (07): : 573 - 580
12345